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Sodium phosphate loading has been shown to increase aerobic capacity and time to exhaustion by enhancing the ability of red blood cells to deliver oxygen to active muscles. The effect of sodium phosphate loading on the lactate threshold and lactate production in resistance training athletes has been studied over multiple studies using a variety of loading procedures, including single bouts of resistance training, high volume low to moderate intensity (HI), or HI and HI with low or low volume (LH) training [10–12,14–16]. Results have shown that sodium phosphate loading to the maximum level (1,200 m.p.h. or greater) decreases rates of muscle damage, with the greatest reduction in damage occurring with moderate intensity (80% of max), low volume (20-40% of max) and HI (10-80% of max) strength training [10,12,14,15]. The decrease in damage occurs mainly because the rate of oxidative stress is decreased to a level comparable to that seen during maximal endurance exercise . Additionally, in addition to reduced muscular damage, studies have found that loading to the maximal levels, for example 800 m.p.h. will increase insulin sensitivity and increase anabolic factors such as testosterone and growth hormone [17–19]. This has led a number of researchers to believe that the physiological advantages of sodium phosphate loading would outweigh the physiological disadvantages. Therefore, the purpose of this review is to examine the physiological and ergogenic benefits of sodium phosphate loading to the neuromuscular system with a specific focus on the performance of resistance and agility training.Aerobic Capacity Studies examining the aerobic capacity of the neuromuscular system during a variety of resistance training protocols have found that there are numerous positive differences between the load (strength training) and the volume of the training (aerobic exercise) used to achieve the same load. While both protocols generally use the same load (50-60% of the max), studies using the strength-only protocol consistently reveal higher rates of oxygen uptake than the study using the aerobic exercise protocol [18–20]. These results have been confirmed by other studies, where performance during high intensity interval training has been consistently higher when compared to the performance during low intensity training, and when compared to the performance during low intensity training . Other studies have reported that the lactate threshold and lactate production are also greater in groups that use anaerobic or high intensity training protocols than the performance during low- to medium-intensity conditions . These studies have also demonstrated that loading to the maximum values (800 m.p.h. or greater) will reduce the rate of muscle damage and injury during these workouts [Similar articles: